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Autism spectrum disorders consist of a range of complex neurodevelopmental disorders characterized by social impairments, communication difficulties, and restricted repetitive and stereotyped patterns of behaviour.
The prevalence of Autism spectrum disorders has increased in recent decades to 0.6-1%. It vary in severity and their clinical phenotypes reflect the multifactorial background.
The developmental changes in autistic brains revealed by brain imaging, candidate gene studies, whole genome sequencing, transcriptomic analysis, and stem cell studies provide new information that improves our understanding of the activity dependent synaptic changes underlying altered function of neuronal networks in autistic brains and the clinical phenotypes of Autism spectrum disorders.
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